Bioassay Technology Laboratory's Caspase 3 p17 Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot.
Description
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits: large and small: that dimerize to form the active enzyme. This protein cleaves and activates caspases 6: 7 and 9: and the protein itself is processed by caspases 8: 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein: which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein